- 22 December 2000 — BOB drops QB Gus Frerotte; adds QB Jon Kitna
- 15 December 2000 — NYG drop K David Akers (Eagles); add K Doug Brien (Saints)
- 10 December 2000 — NYG drop K John Hall (Jets); add K David Akers (Eagles)
- 30 November 2000 — GBM drops K Jeff Hall (Rams); adds QB Aaron Brooks (Saints)
- 29 November 2000 — BOB drops QB Jim Miller (Bears); adds QB Gus Frerotte (Broncos)
- 29 November 2000 — NYG drop RB Frank Moreau (Chiefts); adds RB Jerald Moore (Falcons)
- 29 November 2000 — BOB transfers WR JuJuan Dawson from 10-week IR to season-long IR
- 29 November 2000 — NDV drops WR Jeremy McDaniel (Bills); adds RB Bernie Parmalee (Jets)
- 28 November 2000 — BOS drops RB Obafemi Ayanbadejo (Ravens); dropped off of injured reserve
- 21 November 2000 — SYR drops TE Itula Mili (Seahawks) and RB Amp Lee (Eagles); adds TE Dwayne Carswell (Broncos) and RB Zack Crockett (Raiders)
- 19 November 2000 — BOS drops RB Doug Chapman (Vikings); adds RB Brad Hoover (Panthers)
- 16 November 2000 — GBM drops TE Stephen Alexander (Redskins); adds K Jeff Hall (Rams)
- 14 November 2000 — GBM places WR Travis Taylor (Ravens) on 5-week IR; adds RB Chad Morton (Saints)
- 14 November 2000 — MVO drops QB Randal Cunningham (Cowboys); adds QB Troy Aikman (Cowboys)
- 14 November 2000 — BOS drops WR Leslie Shepherd (Dolphins); adds WR James McKnight (Cowboys)
- 14 November 2000 — BOS drops RB Shyrone Stith (Jaguars); adds RB Terry Allen (Saints)
- 12 November 2000 — NDV drops RB Natrone Means; adds TE Casey Crawford (Panthers)
- 7 November 2000 — GBM drops K Pete Stoyanovich; adds WR Travis Taylor (Ravens)
- 7 November 2000 — MVO places WR Raghib Ismail on season-ending IR; adds TE Bubba Franks
- 7 November 2000 — KEY drops TE Dwayne Carswell (Broncos); adds TE Ricky Dudley (Raiders)
- 5 November 2000 — NDV places TE Wesley Walls on season-ending IR; adds TE Jackie Harris (Cowboys)
- 4 November 2000 — SYR drops K Kris Brown (Steelers); adds RB Amp Lee (Eagles)
- 4 Novmeber 2000 — BOS drops TE Ricky DUDley (Raiders); adds WR Derrick Mayes (Seahawks)
- 4 November 2000 — KEY drops WR Travis Taylor (Ravens); activates TE Jay Riemersma from IR
- 2 November 2000 — FFL drops QB Doug Pederson (Browns); adds RB Garrison Hearst (49ers)
- 1 November 2000 — SYR drops QB Troy Aikman (Cowboys); adds RB Mario Bates (Lions)
- 31 October 2000 — KEY drops K John Carney (Chargers); adds K Steve Christie (Bills)
- 31 October 2000 — BOS drops WR Reggie Jones (Chargers) and K Todd Peterson (Chiefs); adds TE Kyle Brady (Jaguars) and K Jason Elam (Broncos)
- 31 October 2000 — FFL drops K Kris Heppner and TE Bubba Franks (Packers); adds WR Alvis Whitted (Jaguars) and QB Tim Couch (Browns)
- 31 October 2000 — MVO drops QB Jon Kitna (Seahawks); adds QB Randal Cunningham (Cowboys)
- 29 October 2000 — KEY drops WR Jerry Porter (Raiders); adds QB Trent Dilfer (Ravens)
- 29 October 2000 — BOS activates K Mike Hollis (Jaguars) off IR; places RB Obafemi Ayanbadejo (Ravens) on 5-week IR
- 26 October 2000 — GBM drops QB Tony Banks (Ravens) and RB Antowin Smith (Bills); adds QB Doug Pederson (Browns) and RB Richie Anderson (Jets)
- 26 October 2000 — NDV drops QB Tim Couch (Browns); adds QB Jay Fiedler (Dolphins)
- 25 OCtober 2000 — BOS drops TE Jackie Harris (Cowboys); adds WR Leslie Shepherd (Dolphins)
- 24 October 2000 — BOS drops WR Derrick Mayes (Seahawks)
- 24 October 2000 — BOB drops QB Akili Smith (Bengals); adds QB Trent Green (Rams)
- 24 October 2000 — MVO drops RB Adrian Murrell (Redskins); adds RB Kimble Anders (Chiefs)
24 October 2000 — NDV drops WR Darin Chiavarini (Browns); activates WR Tim Dwight (Falcons) off IR - 19 October 2000 — RMD drops K Jason Elam (Broncos)
- 19 October 2000 — BOS drops WR David Patten (Browns); adds RB Shyrone Stith (Jaguars)
- 18 October 2000 — SYR places RB Erict Rhett (Browns) on season-long IR; adds TE Itula Mili (Seahawks)
- 18 October 2000 — SYR drops RB Basil Mitchell (Packers); adds K Kris Brown (Steelers)
- 18 October 2000 — GBM drops RB Moe Williams (Vikings); adds K Pete Stoyanovich (Rams)
- 17 October 2000 — NVD drops RB Amp Lee (Eagles); adds QB Doug Flutie (Bills)
- 17 October 2000 — BOB drops RB Mike Cloud (Chiefs); adds RB Sammy Morris (Bills)
- 15 October 2000 — NDV places RB Duce Staley (Eagles) in season-long IR; adds RB Amp Lee (Eagles)
- 15 October 2000 — BOS drops WR Marty Booker (Bears); adds RB Doug Chapman (Vikings)
- 14 October 2000 — FFL drops WR Todd Pinkston (Eagles); adds K Kris Heppner (Redskins)
- 14 October 2000 — BOB drops WR E.G. Green (Colts); adds RB Chris Fuamatu-Maafala (Steelers)
- 13 October 2000 — MIA drops TE David Sloan (Lions); adds K Adam Vinatieri (Patriots)
- 12 October 2000 — GBM drops K Wade Richey (49ers); adds WR James Thrash (Redskins)
- 11 October 2000 — BOS drops K Rian Lindell (Seahawks) and RB Stacey Mack (Jaguars); adds K Todd Peterson (Chiefs) and WR Reggie Jones (Chargers)
- 10 October 2000 — MVO drops RB Raymont Harris (Broncos); adds RB Darnell Autrey (Eagles)
- 8 October 2000 — NYG drop K Pete Stoyanovich (Chiefs); add TE Chad Lewis (Eagles)
- 5 October 2000 — BOS drops QB Neil O’Donnell (Titans); adds WR David Patten (Browns)
- 5 October 2000 — MVO drops WR Jeff Graham (Chargers); adds WR Derrick Mason (Titans)
- 5 October 2000 — GMB drops WR Matthew Hatchette (Vikings); adds K Wade Richey (49ers)
- 4 October 2000 — NPB trades WR Keyshawn Johnson (Bucs) to NYG for WR Bill Schroeder (Packers) and 2nd round draft pick in 2001
- 4 October 2000 — NPB trades RB Corey Dillon (Bengals) to BOS for RB Curtis Enis (Bears) and 2nd round draft pick in 2001
- 3 October 2000 — NYG drop TE Kyle Brady (Jaguars); adds K John Hall (Jets)
- 3 October 2000 — MVO drops TE David LaFleur (Cowboys); adds WR Torrance Small (Eagles)
- 3 October 2000 — NDV drops WR Andre Reed (Redskins) and WR Sean Dawkins (Seahawks); adds RB Justin Watson (Rams) and RB Brian Mitchell (Eagles)
- 1 October 2000 — KEY places TE Jay Riemersma (Bills) on 5-week IR; adds TE Dwayne Carswell (Broncos)
- 1 October 2000 — MER drops K Brett Conway; adds TE Eric Bjornson (Patriots)
- 29 September 2000 — NYG drop K John Hall (Jets); add K Pete Stoyanovich (Chiefs)
- 28 September 2000 — MVO places WR Kevin Dyson (Titans) on season-long IR; adds TE Freddie Jones (Chargers)
- 27 September 2000 — BOS drops K Doug Brien (Saints); adds K Rian Lindell (Seahawks)
- 27 September 2000 — MER drops K Michael Husted (Redskins); adds K Gary Anderson (Vikings)
- 26 September 2000 — BOS drops WR Yancey Thigpen (Titans); adds TE Jacke Harris (Cowboys)
- 24 September 2000 — NDV places WR Tim Dwight (Falcons) on 5-week IR; adds WR Darrin Chiaverini (Browns)
- 23 September 2000 — BOB drops D Brad Daluiso (Giants) and RB Travis Jervey (49ers); adds QB Jim Miller (Bears) and TE Ken Dilger (Colts)
- 23 September 2000 — BOS places WR Derrick Mayes (Seahawks) on 5-week IR; adds WR Marty Booker (Bears)
- 21 September 2000 — SYR places WR Bobby Engram (Bears) on season-long IR; adds WR Chris Sanders (Titans)
- 20 September 2000 — BOS places K Mike Hollis (Jaguars) on 5-week IR; adds RB Obafemi Ayanbadejo (Ravens)
- 20 September 2000 — GBM drops TE Freddie Jones (Chargers); adds RB Terrell Fletcher (Chargers)
- 20 September 2000 — MER drops TE Marcus Pollard (Colts); adds K Michael Husted (Redskins)
- 19 September 2000 — MVO drops K Gary Anderson (Vikings); adds K Morten Anderson (Falcons)
- 19 September 2000 — NDV drops K Adam Vinatieri (Patriots); adds WR Jeremy McDaniel (Bills)
- 17 September 2000 — BOS drops RB Terry Jackson (49ers); adds K Doug Brien (Saints)
- 17 September 2000 — BOS drops RB Doug Chapman (Vikings); adds QB Jeff Garcia (49ers)
15 September 2000 — RMD drops K Todd Peterson (free agent); adds K Cary Blanchard (Cardinals) - 15 September 2000 — RMD places K Jason Elam (Broncos) on 5-week IR; adds K Joe Nedney (Broncos)
- 15 September 2000 — BOB places WR JuJuan Dawson (Browns) on 10-week IR; adds WR Darrell Jackson (Seahawks)
- 15 September 2000 — BOB drops WR Reidel Anthony (Bucs); adds K Brad Daluiso (Giants)
- 14 September 2000 — NYG drop RB Chris Howard (formerly Jaguars); adds RB Fred Beasley (49ers)
- 13 September 2000 — NDV drops WRs Vincent Brisby (Jets) and Hines Ward (Steelers); adds WR Andre Reed (Redskins) and K Adam Vinatieri (Patriots)
- 13 September 2000 — MVO drops RB Reuben Droughns (Lions); adds RB Raymont Harris (Broncos)
- 13 September 2000 — MIA drops WR Torrance Small (Eagles); adds RB Larry Centers (Redskins)
- 12 September 2000 — GBM place WR Michael Westbrook (Redskins) on IR; add TE Stephen Alexander (Redskins)
- 10 September 2000 — MER drops WR Kevin Lockett (Chiefs); adds WR Ron Dugans (Bengals)
- 8 September 2000 — NYG place RB Olandis Gary (Broncos) on IR; adds TE Kyle Brady (Jaguars)
- 5 September 2000 — KEY puts WR Joey Galloway (Cowbys) on season-long Injured Reserve; adds RB Robert Holcombe (Rams)
- 5 September 2000 — BOS drops RB Abdul-Karim al-Jabbar (Colts); adds RB Mike Anderson (Broncos)
- 5 September 2000 — NYG drop TE Stephen Alexander (Redskins); add RB Chris Howard (Jaguars)
- 3 September 2000 — MIA drops RB Raymont Harris (free agent); adds TE David Sloan (Lions)
- 2 September 2000 — BOS drops RB Amos Zereoue (Steelers); adds RB Terry Jackson (49ers)
- 31 August 2000 — GBM drops RB Cory Schlesinger (Lions); adds TE Freddie Jones (Chargers)
- 30 August 2000 — NPB drops RB Terry Kirby (free agent); adds RB Ki-Jana Carter (free agent)
- 30 August 2000 — KEY drops K John Kasay (Panthers); adds K John Carney (Chargers)
- 26 August 2000 — FFL places WR Patrick Jeffers (Panthers) on IR; adds WR Laveranues Coles (Jets)
- 26 August 2000 — NYG trades draft pick 2000(2) to NDV for draft pick 2001(2)
- 17 August 2000 — BOS trades WR Germaine Crowell (Lions) to FFL for RB Curtis Enis (Bears)
- 16 August 2000 — KEY trades QB Peyton Manning (Colts) 2000(3) draft pick and 2001(5) draft pick to New York for RB Marshall Faulk (Rams), QB Brad Johnson (Redskins), 2000 (2 – 23rd overall) draft pick and 2001(6) draft pick
- 16 August 2000 — KEY trades RB Corey Dillon (Bengals) and 2000(4) draft pick to NPB for WR Joey Galloway (Cowboys) and 2000(3) draft pick
- 12 July 2000 — MVO trades QB Steve Beuerlein (Panthers) to NPB for WR Kevin Johnson (Browns)
Traded Draft Picks (2001 and beyond)
- NPB has NYG’s 2001(2) – Johnson/Schroeder deal
- NPB has BOS’s 2001(2) – Dillon/Enis deal
- KEY has NYG’s 2001(6) – Faulk/Manning deal
- NYG has KEY’s 2001(5) – Faulk/Manning deal
- NYG has DAL’s 2001(1) – Brunnell/Marino deal
- NYG has NDV’s 2001(2) – draft pick exchanges (26 Aug 2000)